Critical Care

Critical Care We deal with two products in critical care.TORAYMYXIN™️ (PMX™️) is an extracorporeal hemoperfusion cartridge designed to remove endotoxin in blood. TORAYMYXIN™️ is indicated for patients with sepsis or septic shock caused by suspected Gram-negative bacterial infection or endotoxemia.

TORAYMYXIN™️ is composed of polymyxin B-immobilized polystyrene derivative fibers. Polymyxin B is an antibiotic which is well known to bind endotoxin selectively.

Systemic use of polymyxin B is restricted due to nephrotoxicity and neurotoxicity. However, TORAYMYXIN™️ selectively removes circulating endotoxin, because polymyxin B is covalently bonded to the fiber.

TORAYMYXIN™️ was approved by the Japanese Ministry of Health and Welfare in 1993, and was listed in national health insurance in 1994. In the worldwide, TORAYMYXIN™️ is launched in more than 10 countries since TORAYMYXIN™️ acquired EC certificate in 1998. Until now, over 150,000 patients have been treated with TORAYMYXIN™️ worldwide.

HEMOFEEL™️ is the new membrane for continuous renal support made of polymethylmethacrylate, a highly hemo- and biocompatible material designed by TORAY – a global leader in advanced materials.

The most fundamental characteristics of a membrane designed for blood purification therapy is to provide maximal hemocompatibility by provoking the least possible inflammatory response in the patients exposed to it. In the setting of AKI, the inflammatory response caused by the dialysis procedure may have clinical consequences such as hemodynamic instability, immune-dysregulation or delayed recovery of renal function.

Polymethylmethacrylate (PMMA) is a synthetic polymer designed to provide maximum hemo- and biocompatibility to the patient as well as ensuring the best renal replacement. PMMA membranes are recognized for their unique hemo- and biocompatibility aimed at improving the patient’s clinical condition with immunoprotective effect.

In addition, the PMMA membrane adds a third dimension to dialysis: ADSORPTION. If through diffusion and convection it is possible to remove molecules of small and medium molecular weight, adding adsorption provides the ability to remove molecules of medium and high molecular weight. The adsorptive capacity is crucial for the removal of molecules involved in the inflammatory cascade, among which cytokines and other inflammatory mediators. HEMOFEEL™️ can therefore be classified as a Cytokine Adsorptive Hemofilter.

HEMOFEEL™️ is a unique membrane, providing therapy at 3 levels:
Immunoprotection
Immunomodulation
Innovative renal support
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